GNG5

Across TCGA pan-cancer cohorts, GNG5 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GNG5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GNG5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GNG5 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where GNG5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.565	<.001	11	view →
LUAD	Female	II,III,IV	−0.372	<.001	9	view →
LSCC	Male	II,III,IV	−0.334	<.001	9	view →
COAD	All	All	−0.225	<.001	8	view →
HNSC	Male	II,III,IV	+0.209	<.001	8	view →
PDAC	Female	II,III,IV	+0.608	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GNG5–CCRCC

Open the CCRCC breakdown →