GNG3

Across TCGA cell cohorts, GNG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,221 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNG3-associated GO terms across cancer lineages are Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, Negative regulation of DNA-templated transcription, elongation, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with GNG3 in more than 14 cancer types. Because this analysis shows association rather than direction, both GNG3-to-partner and partner-to-GNG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway grouped by GNG3-low versus GNG3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG3→partner) and Y-score (partner→GNG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.128	+0.486	<.001	<.001	3	15
SOFT_TISSUE	Negative regulation of DNA-templated transcription, elongation →	+0.125	+1.047	<.001	.001	3	14
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.209	+0.582	<.001	<.001	3	14
BONE	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.170	+0.517	<.001	.005	3	14
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.079	+0.615	<.001	<.001	2	14
BONE	Negative regulation of mRNA processing →	+0.139	+0.790	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,221 associations by consensus.

Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway by GNG3 expression — PANCREAS

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