Across TCGA patient cohorts, GNG2 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG2-associated genes across cancer lineages are RNA5SP463, IGHD1-1, and MIR8081. Each is linked with GNG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG2-to-partner and partner-to-GNG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG2→partner) and Y-score (partner→GNG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP463 →	+0.628	+2.580	<.001	.009	3	2
UCEC	IGHD1-1 →	+1.088	+4.335	<.001	<.001	3	2
BRCA	MIR8081 →	+0.643	+5.841	<.001	.003	3	1
BRCA	RNA5SP75 →	+0.407	+5.203	<.001	.007	3	1
BRCA	CKBP1 →	+0.084	+5.122	<.001	.008	3	1
BRCA	MIR3617 →	+0.526	+5.259	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Exploration

GNG2 survival (RNA) · tumor vs normal (RNA) · all GNG2 data types