GNG12-AS1

Across TCGA pan-cancer cohorts, GNG12-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GNG12-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNG12-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GNG12-AS1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and BLCA are the cancer types where GNG12-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG12-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.732	<.001	10	view →
THCA	Female	II,III,IV	−0.467	<.001	10	view →
BLCA	Male	All	−0.868	<.001	8	view →
READ	All	II,III,IV	−0.955	<.001	7	view →
LUSC	Female	II,III,IV	−0.604	<.001	7	view →
LIHC	Female	All	−0.230	<.001	7	view →
KIRC	All	II,III,IV	−0.189	.004	7	view →
BRCA	All	III,IV	−0.962	<.001	6	view →
UCEC	All	All	−0.476	<.001	4	view →
KIRP	Male	All	−0.243	.001	4	view →
KICH	Male	III,IV	−0.464	.016	3	view →
LUAD	Female	II,III,IV	−0.319	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GNG12-AS1–COAD

Open the COAD breakdown →