GNG11

Across TCGA patient cohorts, GNG11 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GNG11-associated genes across cancer lineages are MIR190A, TMEM225, and RNU6-784P. Each is linked with GNG11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG11-to-partner and partner-to-GNG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR190A grouped by GNG11-low versus GNG11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG11→partner) and Y-score (partner→GNG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR190A →	+0.565	+6.917	<.001	<.001	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1
READ	RNU6-784P →	+0.379	+6.257	<.001	.001	3	1
READ	B3GALNT2P1 →	+0.122	+5.421	<.001	.005	3	1
READ	ABCD1P4 →	+0.117	+5.219	<.001	.006	3	1
READ	LINC00440 →	+0.065	+6.681	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

MIR190A by GNG11 expression — COAD

Explore this box plot interactively →