GNG11

Across TCGA pan-cancer cohorts, GNG11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GNG11’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GNG11 RNA is repressed in tumor relative to normal tissue. In most cancer types GNG11 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRC are the cancer types where GNG11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.472	<.001	11	view →
THCA	All	IV	−1.822	<.001	11	view →
KIRC	Male	All	+1.047	<.001	10	view →
LUSC	Male	III,IV	−3.457	<.001	9	view →
UCEC	All	III,IV	−3.022	<.001	8	view →
LUAD	Female	III,IV	−2.793	<.001	8	view →
COAD	All	All	−0.862	<.001	7	view →
BRCA	All	II,III,IV	−1.998	<.001	6	view →
KIRP	All	III,IV	+1.107	.003	5	view →
LIHC	All	All	+0.398	.004	4	view →
PRAD	All	All	−1.127	<.001	2	view →
READ	Female	All	−1.968	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GNG11–BLCA

Open the BLCA breakdown →