GNG10

Across TCGA patient cohorts, GNG10 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG10-associated genes across cancer lineages are LINC00550, RPL23AP86, and SNRPGP17. Each is linked with GNG10 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG10-to-partner and partner-to-GNG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00550 grouped by GNG10-low versus GNG10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG10→partner) and Y-score (partner→GNG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00550 →	+0.089	+4.383	.005	.001	3	1
UCEC	RPL23AP86 →	+0.288	+3.738	.002	.006	3	1
UCEC	SNRPGP17 →	+0.532	+4.200	<.001	.002	3	1
UCEC	ATF4P2 →	+0.045	+3.599	<.001	.007	3	1
UCEC	RN7SL248P →	+0.137	+4.722	<.001	.004	3	1
UCEC	GRAMD4P4 →	+0.400	+3.334	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

LINC00550 by GNG10 expression — UCEC

Explore this box plot interactively →