GNE

Across TCGA patient cohorts, GNE protein abundance is significantly associated with the RNA expression of many other genes, with 8,858 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GNE-associated genes across cancer lineages are RNF38, RNU4-53P, and RAB27A. Each is linked with GNE in more than 3 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNE versus RNF38 in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF38 →	+0.557	+0.314	.007	.003	3	4
HNSC	RNU4-53P →	+1.244	+0.340	<.001	<.001	3	4
UCEC	RAB27A →	+0.519	+0.352	.002	.002	3	4
GBM	SNN →	-0.762	-0.362	<.001	<.001	3	4
LSCC	CREB3 →	+0.469	+0.310	<.001	<.001	3	4
COAD	SMC2 →	+0.724	+0.651	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,858 associations by consensus.

GNE vs RNF38 — HNSC

Explore this scatter interactively →