GNB3

Across TCGA patient cohorts, GNB3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,349 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNB3-associated genes across cancer lineages are PDIA4, LINC02150, and PYCR3. Each is linked with GNB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNB3-to-partner and partner-to-GNB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNB3 versus PDIA4 in PDAC, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB3→partner) and Y-score (partner→GNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PDIA4 →	-0.934	-1.740	<.001	<.001	3	3
GBM	LINC02150 →	+0.326	+0.633	.008	.005	3	2
LSCC	PYCR3 →	-0.826	-0.440	<.001	<.001	3	2
PDAC	KCNS1 →	-0.669	-1.568	.008	.005	3	2
LSCC	DLK2 →	-0.940	-0.438	<.001	<.001	3	2
COAD	ANXA2R →	+0.631	+0.625	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,349 associations by consensus.

GNB3 vs PDIA4 — PDAC

Explore this scatter interactively →