GNAT2

Across TCGA patient cohorts, GNAT2 mutation is significantly associated with the RNA expression of many other genes, with 460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAT2-associated genes across cancer lineages are NMBR-AS1, RPL7AP23, and LINC02641. Each is linked with GNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAT2-to-partner and partner-to-GNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMBR-AS1 grouped by GNAT2-low versus GNAT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAT2→partner) and Y-score (partner→GNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NMBR-AS1 →	+0.226	+5.513	<.001	<.001	3	2
UCEC	RPL7AP23 →	+0.051	+2.105	.002	.006	3	2
UCEC	LINC02641 →	+0.165	+2.131	.002	.003	3	2
COAD	HMGB3P11 →	+0.159	+5.145	.002	.007	3	1
COAD	LINC00229 →	+0.724	+5.283	<.001	.006	3	1
SKCM	LINC02559 →	+0.128	+4.624	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 460 associations by consensus.

NMBR-AS1 by GNAT2 expression — SKCM

Explore this box plot interactively →