GNAS

Across TCGA cell cohorts, GNAS mutation is significantly associated with the RNA expression of many other genes, with 1,125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNAS-associated genes across cancer lineages are CCER1, RCC1, and ANP32E. Each is linked with GNAS in more than 2 cancer types. Because this analysis shows association rather than direction, both GNAS-to-partner and partner-to-GNAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCER1 grouped by GNAS-low versus GNAS-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAS→partner) and Y-score (partner→GNAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCER1 →	+0.022	+4.643	<.001	.004	3	3
STOMACH	RCC1 →	+0.810	+3.137	.002	.001	3	3
LARGE_INTESTINE	ANP32E →	+0.567	+2.364	.007	<.001	3	3
LARGE_INTESTINE	SCD5 →	+0.994	+1.807	.004	.005	3	3
LARGE_INTESTINE	ZNF232 →	+0.789	+2.087	<.001	.001	3	3
LARGE_INTESTINE	MSH4 →	+0.170	+2.459	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,125 associations by consensus.

CCER1 by GNAS expression — LUNG_SCLC

Explore this box plot interactively →