GNAS-AS1

Across TCGA pan-cancer cohorts, GNAS-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GNAS-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GNAS-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNAS-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

KIRC, UCS, and CESC are the cancer types where GNAS-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.514	0.727	<.001	150	view →
UCS	DFS	Median	II,III,IV	0.582	0.134	<.001	92	view →
CESC	OS	Median	All	0.487	0.668	<.001	84	view →
LGG	DFS	Median	All	0.615	0.852	<.001	54	view →
UCEC	OS	Quartile	All	0.525	0.797	<.001	34	view →
ACC	DFS	Tertile	III,IV	0.823	0.130	.001	30	view →
SKCM	OS	Median	All	0.812	0.921	.001	22	view →
THYM	DFS	Tertile	All	0.953	0.763	.003	21	view →
LIHC	OS	Tertile	II,III,IV	0.247	0.474	.006	21	view →
COAD	OS	Median	II,III,IV	0.541	0.668	.027	15	view →
MESO	OS	Tertile	III,IV	0.426	0.692	.008	12	view →
GBM	OS	Tertile	All	0.486	0.308	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GNAS-AS1–KIRC (DFS)

Open the KIRC breakdown →