GNAS-AS1

Across TCGA pan-cancer cohorts, GNAS-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GNAS-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GNAS-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GNAS-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LUSC, and THCA are the cancer types where GNAS-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNAS-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.250	<.001	5	view →
LUSC	All	All	+0.244	<.001	4	view →
THCA	Male	All	−0.187	.002	4	view →
BRCA	All	All	−0.148	.001	4	view →
CHOL	All	All	+0.217	.011	2	view →
PRAD	All	All	−0.091	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GNAS-AS1–KICH

Open the KICH breakdown →