GNAL

Across TCGA patient cohorts, GNAL mutation is significantly associated with the RNA expression of many other genes, with 4,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAL-associated genes across cancer lineages are GPR53P, RPS29P13, and NBEAP5. Each is linked with GNAL in more than 2 cancer types. Because this analysis shows association rather than direction, both GNAL-to-partner and partner-to-GNAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR53P grouped by GNAL-low versus GNAL-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAL→partner) and Y-score (partner→GNAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPR53P →	+0.035	+4.505	.001	.009	3	3
THCA	RPS29P13 →	+0.148	+7.962	<.001	.007	3	2
CESC	NBEAP5 →	+0.112	+4.384	<.001	.008	3	2
COAD	LINC00158 →	+0.152	+2.947	<.001	.007	3	2
COAD	ELK2BP →	+0.102	+3.003	.003	.003	3	2
COAD	IGKV1-37 →	+0.361	+2.857	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,606 associations by consensus.

GPR53P by GNAL expression — HNSC

Explore this box plot interactively →