GNAI2

Across TCGA patient cohorts, GNAI2 mutation is significantly associated with the RNA expression of many other genes, with 1,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAI2-associated genes across cancer lineages are SEZ6L-AS1, CTLA4, and RELL2. Each is linked with GNAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAI2-to-partner and partner-to-GNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEZ6L-AS1 grouped by GNAI2-low versus GNAI2-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI2→partner) and Y-score (partner→GNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	SEZ6L-AS1 →	+0.104	+5.068	<.001	.008	3	2
UCEC	CTLA4 →	+0.772	+2.435	<.001	<.001	3	2
UCEC	RELL2 →	+0.379	+3.512	.005	.002	3	2
UCEC	EN2 →	+1.060	+3.627	.002	.001	3	2
UCEC	FAM90A1 →	-0.659	-2.689	.003	.005	3	2
UCEC	GATD1 →	+0.419	+2.939	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,712 associations by consensus.

SEZ6L-AS1 by GNAI2 expression — ESCA

Explore this box plot interactively →