GNAI2

Across TCGA patient cohorts, GNAI2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAI2-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and MEK1. Each is linked with GNAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAI2-to-partner and partner-to-GNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GNAI2-low versus GNAI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI2→partner) and Y-score (partner→GNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.189	+3.321	.010	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+1.060	+2.926	<.001	<.001	3	2
UCEC	MEK1 →	+0.311	+2.115	.026	.017	3	1
UCEC	MSH2 →	-0.300	-2.212	<.001	.010	3	1
UCEC	MSH6 →	-0.471	-2.700	<.001	.005	3	1
UCEC	PDCD4 →	-0.446	-1.874	.013	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by GNAI2 expression — UCEC

Explore this box plot interactively →