GNA15

Across TCGA cell cohorts, GNA15 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNA15-associated genes across cancer lineages are SLC5A5, MSGN1, and CFAP47. Each is linked with GNA15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA15-to-partner and partner-to-GNA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A5 grouped by GNA15-low versus GNA15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA15→partner) and Y-score (partner→GNA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC5A5 →	+0.369	+3.453	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CFAP47 →	+0.201	+3.453	.007	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ASB18 →	+0.085	+3.938	<.001	.002	3	1
LARGE_INTESTINE	FAM153B →	+0.639	+3.748	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SLC5A5 by GNA15 expression — LARGE_INTESTINE

Explore this box plot interactively →