GNA14

Across TCGA pan-cancer cohorts, GNA14 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNA14 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GNA14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GNA14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, KICH, and BRCA are the cancer types where GNA14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
BRCA	OS	Median	II,III,IV	0.583	0.913	<.001	30	view →
UCEC	DFS	Median	All	1.000	0.617	.005	30	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNA14–KIRC (OS)

Open the KIRC breakdown →