GNA14

Across TCGA patient cohorts, GNA14 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA14-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with GNA14 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA14-to-partner and partner-to-GNA14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GNA14-low versus GNA14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA14→partner) and Y-score (partner→GNA14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.254	-3.584	.004	.002	3	1
UCEC	EGFR →	-0.141	-2.321	.014	.034	3	1
UCEC	eIF4E →	+0.220	+2.321	.003	.001	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.000	<.001	<.001	3	1
UCEC	Fibronectin →	-0.236	-1.584	.046	.019	3	1
UCEC	FoxM1 →	+0.308	+1.925	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

EGFR_pY1068 by GNA14 expression — UCEC

Explore this box plot interactively →