GNA12

Across TCGA patient cohorts, GNA12 mutation is significantly associated with the RNA expression of many other genes, with 1,436 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA12-associated genes across cancer lineages are THRB, LURAP1L, and SKA1. Each is linked with GNA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA12-to-partner and partner-to-GNA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THRB grouped by GNA12-low versus GNA12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA12→partner) and Y-score (partner→GNA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THRB →	-0.732	-2.502	<.001	<.001	3	2
UCEC	LURAP1L →	-0.962	-3.044	<.001	<.001	3	2
UCEC	SKA1 →	+0.574	+2.346	.001	.003	3	2
UCEC	MST1R →	+0.864	+1.807	<.001	.004	3	2
UCEC	SRP68 →	+0.317	+2.148	.008	<.001	3	2
UCEC	REEP4 →	+0.491	+2.828	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,436 associations by consensus.

THRB by GNA12 expression — UCEC

Explore this box plot interactively →