GNA12

Across TCGA patient cohorts, GNA12 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA12-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eEF2. Each is linked with GNA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA12-to-partner and partner-to-GNA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GNA12-low versus GNA12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA12→partner) and Y-score (partner→GNA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.437	-1.807	.006	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.981	+2.434	<.001	.001	3	2
UCEC	eEF2 →	+0.280	+2.459	.026	.018	3	1
UCEC	EGFR_pY1068 →	-0.186	-1.807	.035	.025	3	1
UCEC	ERK2 →	+0.198	+2.000	.003	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.135	-1.584	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by GNA12 expression — UCEC

Explore this box plot interactively →