GNA12

Across TCGA cell cohorts, GNA12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,947 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GNA12-associated GO terms across cancer lineages are Protein localization to endosome, Positive regulation of stress fiber assembly, and Caveolin-mediated endocytosis. Each is linked with GNA12 in more than 15 cancer types. Because this analysis shows association rather than direction, both GNA12-to-partner and partner-to-GNA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endosome grouped by GNA12-low versus GNA12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA12→partner) and Y-score (partner→GNA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to endosome →	+0.177	+0.893	<.001	<.001	3	16
BONE	Positive regulation of stress fiber assembly →	+0.153	+1.026	.002	.002	3	14
BONE	Caveolin-mediated endocytosis →	+0.156	+0.968	.001	.003	3	14
OESOPHAGUS	Response to oscillatory fluid shear stress →	+0.160	+0.996	.005	.005	1	16
OESOPHAGUS	Cellular response to oscillatory fluid shear stress →	+0.160	+0.996	.005	.005	1	16
OESOPHAGUS	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.160	+0.996	.005	.005	1	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,947 associations by consensus.

Protein localization to endosome by GNA12 expression — BONE

Explore this box plot interactively →