GNA11

Across TCGA pan-cancer cohorts, GNA11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GNA11 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GNA11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNA11 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

HNSC, GBM, and PDAC are the cancer types where GNA11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.177	1.000	.010	51	view →
GBM	DFS	Quartile	All	0.898	0.603	.003	9	view →
PDAC	OS	Median	IV	0.381	0.951	.006	6	view →
CCRCC	OS	Tertile	All	1.000	0.630	.018	4	view →
LUAD	DFS	Quartile	II,III,IV	0.447	0.795	.027	2	view →
LSCC	OS	Median	All	1.000	0.800	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GNA11–HNSC (DFS)

Open the HNSC breakdown →