GNA11

Across TCGA pan-cancer cohorts, GNA11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GNA11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNA11 RNA is repressed in tumor relative to normal tissue. In most cancer types GNA11 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where GNA11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNA11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.582	<.001	11	view →
KIRC	Male	II,III,IV	−0.590	<.001	11	view →
THCA	Male	II,III,IV	−0.490	<.001	10	view →
BLCA	All	IV	−0.818	.001	8	view →
LIHC	Female	All	+0.693	<.001	8	view →
KIRP	Male	All	−0.726	<.001	7	view →
LUAD	Female	All	−0.687	<.001	7	view →
UCEC	All	All	−1.084	<.001	6	view →
READ	All	All	−1.406	<.001	5	view →
KICH	Female	II,III,IV	+1.150	<.001	5	view →
BRCA	Female	II,III,IV	−0.290	<.001	4	view →
CHOL	Male	All	+1.796	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GNA11–COAD

Open the COAD breakdown →