GNA11

Across TCGA patient cohorts, GNA11 protein abundance is significantly associated with the RNA expression of many other genes, with 11,748 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNA11-associated genes across cancer lineages are CIRBP, TLE5, and ZNF77. Each is linked with GNA11 in more than 6 cancer types. Because this analysis shows association rather than direction, both GNA11-to-partner and partner-to-GNA11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNA11 versus CIRBP in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA11→partner) and Y-score (partner→GNA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CIRBP →	+0.780	+0.381	<.001	<.001	3	7
OV	TLE5 →	+0.821	+0.421	<.001	<.001	3	6
OV	ZNF77 →	+0.531	+0.297	.001	.004	3	6
UCEC	TTK →	-1.033	-0.237	.001	.008	3	5
GBM	CD180 →	-0.633	-0.295	.003	<.001	3	5
BRCA	HMGA1 →	-0.844	-0.325	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,748 associations by consensus.

GNA11 vs CIRBP — OV

Explore this scatter interactively →