GNA11

Across TCGA patient cohorts, GNA11 mutation is significantly associated with the RNA expression of many other genes, with 1,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA11-associated genes across cancer lineages are RNU7-181P, OR8B4, and TUBAP7. Each is linked with GNA11 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNA11-to-partner and partner-to-GNA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-181P grouped by GNA11-low versus GNA11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA11→partner) and Y-score (partner→GNA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-181P →	+0.554	+3.253	<.001	.003	3	3
HNSC	OR8B4 →	+0.039	+7.954	<.001	.008	3	2
CESC	TUBAP7 →	+0.067	+4.824	<.001	<.001	3	2
SKCM	RN7SL429P →	+0.096	+4.634	<.001	.003	3	2
SKCM	RNU5A-3P →	+0.328	+3.180	<.001	.004	3	2
SKCM	MIR548S →	+0.194	+4.408	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,183 associations by consensus.

RNU7-181P by GNA11 expression — SKCM

Explore this box plot interactively →