GNA11

Across TCGA patient cohorts, GNA11 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA11-associated genes across cancer lineages are VHL, JNK_pT183_Y185, and Ku80. Each is linked with GNA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA11-to-partner and partner-to-GNA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GNA11-low versus GNA11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA11→partner) and Y-score (partner→GNA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.015	-3.321	.002	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-2.308	.018	.036	3	1
UCEC	Ku80 →	+0.246	+2.335	.038	.020	3	1
UCEC	p62 Lck ligand →	+0.555	+3.009	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.400	-3.169	.002	.018	3	1
UCEC	ATM →	-0.560	-2.321	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

VHL by GNA11 expression — UCEC

Explore this box plot interactively →