GNA11

Across TCGA cell cohorts, GNA11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,025 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GNA11-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Mitotic chromosome condensation. Each is linked with GNA11 in more than 15 cancer types. Because this analysis shows association rather than direction, both GNA11-to-partner and partner-to-GNA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by GNA11-low versus GNA11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA11→partner) and Y-score (partner→GNA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.135	+0.741	.002	<.001	3	16
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.170	+0.664	.006	.004	3	15
LUNG_NSCLC_LUSC	Mitotic chromosome condensation →	+0.130	+0.765	.006	.002	3	14
LUNG_NSCLC_LUSC	Positive regulation of mitotic cytokinesis →	+0.135	+0.899	.002	<.001	3	14
OESOPHAGUS	Regulation of autophagosome maturation →	+0.096	+0.865	.001	.005	3	14
BLOOD_Leukemia	Phospholipase C-activating dopamine receptor signaling pathway →	+1.396	+1.461	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,025 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by GNA11 expression — BONE

Explore this box plot interactively →