GMPS

Across TCGA pan-cancer cohorts, GMPS mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GMPS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GMPS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GMPS is over-expressed in tumor.

COAD, HNSC, and CCRCC are the cancer types where GMPS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GMPS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.556	<.001	12	view →
HNSC	Male	IV	+0.480	<.001	11	view →
CCRCC	All	III,IV	+0.139	<.001	11	view →
LUAD	Female	II,III,IV	+0.472	<.001	9	view →
LSCC	Male	II,III,IV	+1.013	<.001	8	view →
OV	All	All	+1.001	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GMPS–COAD

Open the COAD breakdown →