GMPS

Across TCGA pan-cancer cohorts, GMPS RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GMPS data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GMPS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GMPS expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCS show a favorable association.

MESO, ACC, and LIHC are the cancer types where GMPS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.368	0.664	<.001	119	view →
ACC	DFS	Median	All	0.364	0.780	<.001	93	view →
LIHC	OS	Median	All	0.707	0.841	<.001	73	view →
UCEC	DFS	Median	All	0.788	0.884	<.001	66	view →
PAAD	OS	Median	All	0.366	0.632	<.001	61	view →
KICH	DFS	Quartile	II,III,IV	0.582	1.000	.004	41	view →
LUAD	OS	Quartile	All	0.593	0.791	<.001	31	view →
LUSC	OS	Quartile	All	0.836	0.711	.004	30	view →
LGG	OS	Median	All	0.734	0.930	<.001	22	view →
UCS	OS	Quartile	II,III,IV	0.487	0.130	.021	18	view →
SARC	DFS	Median	All	0.547	0.672	.005	15	view →
KIRP	DFS	Quartile	All	0.774	0.926	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GMPS–MESO (OS)

Open the MESO breakdown →