GMPS

Across TCGA cell cohorts, GMPS mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GMPS-associated genes across cancer lineages are MAGEB4, AVP, and PLVAP. Each is linked with GMPS in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPS-to-partner and partner-to-GMPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by GMPS-low versus GMPS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPS→partner) and Y-score (partner→GMPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	2
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	PLVAP →	+0.230	+3.426	<.001	.007	3	1
LARGE_INTESTINE	CCDC54 →	+0.116	+3.736	.001	.004	3	1
LARGE_INTESTINE	LMNTD1 →	+0.183	+2.969	<.001	.007	3	1
LARGE_INTESTINE	SPINK9 →	+0.255	+3.115	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MAGEB4 by GMPS expression — LARGE_INTESTINE

Explore this box plot interactively →