GMNN

Across TCGA pan-cancer cohorts, GMNN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GMNN data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GMNN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GMNN expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where GMNN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.352	0.821	.001	42	view →
PDAC	DFS	Median	All	0.633	0.868	.032	4	view →
LSCC	OS	Median	All	0.959	0.733	.028	4	view →
LUAD	DFS	Median	All	0.437	1.000	.018	2	view →
GBM	OS	Tertile	All	0.227	0.762	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GMNN–HNSC (DFS)

Open the HNSC breakdown →