GML

Across TCGA pan-cancer cohorts, GML Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GML data layer compared with 13 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GML Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GML expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

COAD, STAD, and SKCM are the cancer types where GML Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.056	0.781	<.001	12	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →
SKCM	DFS	Median	All	0.371	0.763	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GML–COAD (OS)

Open the COAD breakdown →