GML

Across TCGA cell cohorts, GML RNA expression is significantly associated with the go_rna of many other GO terms, with 368 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GML-associated GO terms across cancer lineages are Regulation of monocyte differentiation, Peptidyl-lysine acetylation, and Positive regulation of receptor localization to synapse. Each is linked with GML in more than 2 cancer types. Because this analysis shows association rather than direction, both GML-to-partner and partner-to-GML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of monocyte differentiation grouped by GML-low versus GML-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GML→partner) and Y-score (partner→GML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of monocyte differentiation →	-0.110	-0.042	.004	.005	3	3
BLOOD_Leukemia	Peptidyl-lysine acetylation →	+0.068	+0.040	.001	.008	3	2
BLOOD_Leukemia	Positive regulation of receptor localization to synapse →	-0.095	-0.026	.003	.002	3	2
BLOOD_Leukemia	Regulation of protein localization to cilium →	+0.098	+0.028	<.001	<.001	3	2
BLOOD_Leukemia	Regulation of CD4-positive, alpha-beta T cell proliferation →	-0.119	-0.027	<.001	.001	3	2
BLOOD_Leukemia	Cranial nerve development →	-0.054	-0.024	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

Regulation of monocyte differentiation by GML expression — BLOOD_Leukemia

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