Across TCGA patient cohorts, GMFB protein abundance is significantly associated with the RNA expression of many other genes, with 10,344 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GMFB-associated genes across cancer lineages are CGRRF1, DHRS7, and ATG14. Each is linked with GMFB in more than 7 cancer types. Because this analysis shows association rather than direction, both GMFB-to-partner and partner-to-GMFB results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFB→partner) and Y-score (partner→GMFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CGRRF1 →	+0.579	+0.385	<.001	<.001	3	7
HNSC	DHRS7 →	+0.689	+0.382	<.001	<.001	3	7
HNSC	ATG14 →	+0.471	+0.354	<.001	<.001	2	8
HNSC	KTN1 →	+0.861	+0.408	<.001	<.001	3	7
HNSC	ACTR10 →	+0.429	+0.387	.002	<.001	2	7
CCRCC	SETD3 →	+0.387	+0.162	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,344 associations by consensus.

Exploration

GMFB survival (RNA) · tumor vs normal (RNA) · all GMFB data types