GM2AP2

Across TCGA pan-cancer cohorts, GM2AP2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GM2AP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GM2AP2 RNA is repressed in tumor relative to normal tissue. In most cancer types GM2AP2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where GM2AP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GM2AP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.105	.001	7	view →
KIRC	All	All	−0.067	.002	5	view →
KIRP	All	IV	−0.262	.039	3	view →
LUSC	Male	All	+0.020	.012	2	view →
THCA	All	All	−0.017	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GM2AP2–KICH

Open the KICH breakdown →