Across TCGA patient cohorts, GM2A RNA expression is significantly associated with the protein abundance of many other proteins, with 15,039 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GM2A-associated proteins across cancer lineages are DOCK8, ANKRD44, and LCP1. Each is linked with GM2A in more than 7 cancer types. Because this analysis shows association rather than direction, both GM2A-to-partner and partner-to-GM2A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GM2A→partner) and Y-score (partner→GM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOCK8 →	+0.457	+0.694	<.001	<.001	3	8
OV	ANKRD44 →	+0.537	+0.668	<.001	<.001	3	8
OV	LCP1 →	+0.679	+0.658	<.001	<.001	3	8
GBM	LCP2 →	+0.544	+0.479	<.001	<.001	3	8
GBM	LSP1 →	+0.752	+0.634	<.001	<.001	3	8
BRCA	WDFY4 →	+0.454	+0.633	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,039 associations by consensus.

Exploration

GM2A survival (RNA) · tumor vs normal (RNA) · all GM2A data types