GLUD2

Across TCGA pan-cancer cohorts, GLUD2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GLUD2 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GLUD2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GLUD2 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

BRCA, ACC, and PRAD are the cancer types where GLUD2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.146	0.833	<.001	12	view →
ACC	DFS	Median	All	0.089	0.666	.010	9	view →
PRAD	DFS	Median	All	0.125	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SCLC	OS	Median	IV	0.938	0.260	.049	3	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GLUD2–BRCA (OS)

Open the BRCA breakdown →