GLUD2

Across TCGA pan-cancer cohorts, GLUD2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GLUD2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GLUD2 RNA is repressed in tumor relative to normal tissue. In most cancer types GLUD2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and KIRP are the cancer types where GLUD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLUD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.395	<.001	9	view →
LUSC	Female	All	−0.392	<.001	4	view →
KIRP	Male	All	−0.690	.001	2	view →
READ	All	All	−0.468	.014	2	view →
LUAD	All	All	+0.225	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GLUD2–KICH

Open the KICH breakdown →