GLUD2

Across TCGA patient cohorts, GLUD2 mutation is significantly associated with the RNA expression of many other genes, with 3,733 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLUD2-associated genes across cancer lineages are XPNPEP1, LDHA, and RNU6ATAC9P. Each is linked with GLUD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GLUD2-to-partner and partner-to-GLUD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XPNPEP1 grouped by GLUD2-low versus GLUD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLUD2→partner) and Y-score (partner→GLUD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XPNPEP1 →	+0.387	+2.258	<.001	<.001	3	4
UCEC	LDHA →	+0.543	+2.662	<.001	<.001	3	4
GBM	RNU6ATAC9P →	+0.336	+4.584	<.001	.007	3	3
UCEC	NOP10 →	+0.425	+1.857	<.001	<.001	3	3
UCEC	ENTPD7 →	+0.528	+1.872	<.001	.004	3	3
UCEC	MAK16 →	+0.473	+2.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,733 associations by consensus.

XPNPEP1 by GLUD2 expression — UCEC

Explore this box plot interactively →