GLUD2

Across TCGA cell cohorts, GLUD2 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLUD2-associated genes across cancer lineages are PRSS54, TBATA, and CCDC113. Each is linked with GLUD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLUD2-to-partner and partner-to-GLUD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by GLUD2-low versus GLUD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLUD2→partner) and Y-score (partner→GLUD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRSS54 →	+0.077	+4.867	<.001	.009	3	2
CNS	TBATA →	+0.023	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	CCDC113 →	+1.059	+3.067	<.001	.009	3	1
LARGE_INTESTINE	PTH2R →	+0.750	+3.781	<.001	.003	3	1
LARGE_INTESTINE	CLTRN →	+1.069	+3.087	.001	.006	3	1
LARGE_INTESTINE	PLPPR1 →	+0.398	+3.452	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PRSS54 by GLUD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →