GLUD1

Across TCGA cell cohorts, GLUD1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLUD1-associated genes across cancer lineages are SH3GL2, LY86, and TAFA1. Each is linked with GLUD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLUD1-to-partner and partner-to-GLUD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by GLUD1-low versus GLUD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLUD1→partner) and Y-score (partner→GLUD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.122	+3.252	.005	.009	3	1
LARGE_INTESTINE	LY86 →	+0.059	+2.872	<.001	.008	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	S100A7A →	+0.056	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	IFNL3 →	+0.100	+5.209	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SH3GL2 by GLUD1 expression — LARGE_INTESTINE

Explore this box plot interactively →