GLUD1

Across TCGA pan-cancer cohorts, GLUD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GLUD1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GLUD1 RNA is repressed in tumor relative to normal tissue. In most cancer types GLUD1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and UCEC are the cancer types where GLUD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLUD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.467	<.001	8	view →
KIRC	Male	All	−0.347	<.001	7	view →
UCEC	All	All	−0.980	<.001	6	view →
KICH	Female	All	−0.898	<.001	6	view →
CHOL	Male	All	−1.703	<.001	5	view →
LIHC	All	All	−0.736	<.001	5	view →
KIRP	Male	All	−0.538	.008	5	view →
PAAD	All	All	+0.345	.030	4	view →
HNSC	All	III,IV	+0.483	.007	3	view →
PRAD	All	All	+0.458	.004	2	view →
LUAD	Female	All	−0.217	.007	2	view →
COAD	Female	IV	−0.700	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GLUD1–THCA

Open the THCA breakdown →