GLT1D1

Across TCGA patient cohorts, GLT1D1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLT1D1-associated genes across cancer lineages are VHL, JNK2, and MEK1. Each is linked with GLT1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLT1D1-to-partner and partner-to-GLT1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GLT1D1-low versus GLT1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLT1D1→partner) and Y-score (partner→GLT1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.660	-1.807	.018	.027	3	2
UCEC	JNK2 →	+0.231	+2.321	.004	.006	3	1
UCEC	MEK1 →	+0.448	+2.807	.003	.003	3	1
UCEC	p62 Lck ligand →	+0.379	+2.469	.004	.010	3	1
UCEC	PDK1_pS241 →	+0.177	+3.026	.011	.018	3	1
UCEC	AMPK_pT172 →	+0.393	+2.335	.020	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

VHL by GLT1D1 expression — UCEC

Explore this box plot interactively →