GLS

Across TCGA patient cohorts, GLS mutation is significantly associated with the RNA expression of many other genes, with 3,770 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLS-associated genes across cancer lineages are BPY2DP, RN7SL369P, and RPL23AP45. Each is linked with GLS in more than 1 cancer types. Because this analysis shows association rather than direction, both GLS-to-partner and partner-to-GLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPY2DP grouped by GLS-low versus GLS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLS→partner) and Y-score (partner→GLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BPY2DP →	+0.359	+6.409	<.001	<.001	3	2
KIRP	RN7SL369P →	+0.171	+4.130	<.001	.001	3	2
BLCA	RPL23AP45 →	+0.173	+5.411	<.001	.005	3	2
BRCA	MIR4444-2 →	+0.562	+4.766	<.001	.003	3	2
LUSC	RNU6-142P →	+0.333	+3.881	<.001	.004	3	2
LUSC	MIR8075 →	+0.276	+4.191	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,770 associations by consensus.

BPY2DP by GLS expression — COAD

Explore this box plot interactively →