GLS

Across TCGA pan-cancer cohorts, GLS RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GLS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GLS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GLS is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where GLS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.718	<.001	12	view →
KICH	Female	II,III,IV	−2.592	<.001	11	view →
KIRC	Male	III,IV	−0.777	<.001	9	view →
LIHC	Female	II,III,IV	+2.050	<.001	7	view →
STAD	All	II,III,IV	+0.901	<.001	7	view →
LUSC	Female	All	−1.072	<.001	6	view →
COAD	Male	II,III,IV	+0.622	<.001	4	view →
BRCA	All	III,IV	−0.435	.009	4	view →
CHOL	All	All	+2.934	<.001	3	view →
ESCA	All	All	+1.432	<.001	3	view →
UCEC	All	All	−1.032	<.001	2	view →
KIRP	Female	II,III,IV	+0.958	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GLS–HNSC

Open the HNSC breakdown →