GLS

Across TCGA patient cohorts, GLS mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLS-associated genes across cancer lineages are ASNS, EGFR_pY1068, and EGFR. Each is linked with GLS in more than 1 cancer types. Because this analysis shows association rather than direction, both GLS-to-partner and partner-to-GLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GLS-low versus GLS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLS→partner) and Y-score (partner→GLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.405	+1.584	.004	.036	3	2
UCEC	EGFR_pY1068 →	-0.294	-2.502	.002	.002	3	1
UCEC	EGFR →	-0.199	-2.000	.001	.010	3	1
UCEC	FoxM1 →	+0.248	+2.502	.014	.002	3	1
UCEC	INPP4B →	-0.313	-3.459	.013	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-1.986	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by GLS expression — UCEC

Explore this box plot interactively →