GLRX

Across TCGA patient cohorts, GLRX mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRX-associated genes across cancer lineages are RBAK-RBAKDN, RN7SL248P, and BUB3. Each is linked with GLRX in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRX-to-partner and partner-to-GLRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBAK-RBAKDN grouped by GLRX-low versus GLRX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRX→partner) and Y-score (partner→GLRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBAK-RBAKDN →	+0.108	+3.938	.001	<.001	3	1
UCEC	RN7SL248P →	+0.132	+4.500	<.001	<.001	3	1
UCEC	BUB3 →	+0.632	+3.210	.002	.009	3	1
UCEC	SFXN1 →	+0.690	+3.191	.001	.009	3	1
UCEC	FBXO22 →	+0.850	+3.212	<.001	.009	3	1
UCEC	TRIAP1 →	+0.585	+3.201	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RBAK-RBAKDN by GLRX expression — UCEC

Explore this box plot interactively →