GLRX

Across TCGA patient cohorts, GLRX mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRX-associated genes across cancer lineages are PCNA, ATM, and Caspase-7-cleavedD198. Each is linked with GLRX in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRX-to-partner and partner-to-GLRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GLRX-low versus GLRX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRX→partner) and Y-score (partner→GLRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.307	+3.169	.009	.019	3	1
UCEC	ATM →	-0.889	-2.986	<.001	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.804	+2.827	.013	.035	3	1
UCEC	MEK1 →	+0.477	+3.169	.017	.020	2	1
UCEC	STAT3_pY705 →	-0.439	-3.169	.002	.020	2	1
UCEC	BRCA2 →	-0.140	-3.162	.045	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PCNA by GLRX expression — UCEC

Explore this box plot interactively →