GLRB

Across TCGA patient cohorts, GLRB mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRB-associated genes across cancer lineages are FOXO3a_pS318_S321, Di-Ras3, and Shc_pY317. Each is linked with GLRB in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRB-to-partner and partner-to-GLRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by GLRB-low versus GLRB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRB→partner) and Y-score (partner→GLRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a_pS318_S321 →	+0.138	+1.457	.003	.014	3	2
SKCM	Di-Ras3 →	+0.109	+1.820	.026	.014	3	2
COAD	Shc_pY317 →	-0.216	-3.313	.006	.010	3	2
COAD	STAT3_pY705 →	-0.272	-3.313	.026	.010	3	2
COAD	4E-BP1_pT70 →	+0.129	+2.178	.022	.035	3	2
UCEC	4E-BP1 →	+0.401	+2.321	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

FOXO3a_pS318_S321 by GLRB expression — SKCM

Explore this box plot interactively →